關於「ASC inflammasome」標籤，搜尋引擎有相關的訊息討論：

The NLRP3 Inflammasome: An Overview of Mechanisms of ... - NCBI。

2019年7月6日 · The pyrin domain of NLRP3 interacts with the pyrin domain of ASC to initiate ... Kuijpers T.W., van den Berg T.K. Human NLRP3 inflammasome ...。

Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like ...。

The WNV-induced innate immune response, including production of antiviral cytokines, is critical for controlling virus infection. The adaptor protein ASC ...。

MAVS Promotes Inflammasome Activation by Targeting ASC for K63 ...。

2015年5月15日 · Deficiency in MAVS or TRAF3 impaired ASC ubiquitination and cytosolic speck formation, and hence reduced inflammasome response upon viral ...。

Structure and assembly of the mouse ASC inflammasome by ... - PNAS。

2015年10月27日 · In particular, the solution structures of isolated human ASC pyrin domain (ASC-PYD) and ASC full-length protein (ASC-FL) have been determined, ...。

Inflammasome: Putting the Pieces Together - Cell Press。

Interestingly, NLRP3PYD and AIM2 induce ASCPYD prion conversion, and both AIM2 and NLRP3 convert full-length ASC (ASCFL) into a self-perpetuating prion. In ...： tw | tw。

ASC filament formation serves as a signal amplification mechanism ...。

2016年6月22日 · A hallmark of inflammasome activation is the ASC speck, ... formation of perinuclear specks in cells expressing mCherry-tagged ASCFL (Fig.。

A phenotypic high-content, high-throughput screen identifies ...。

2021年7月28日 · Our high-content screening assay yielded robust assay metrics and identified a number of inhibitors of NLRP3-dependent ASC speck formation, ...。

Regulation of NLRP3 Inflammasome by Phosphorylation - Frontiers。

2018年10月8日 · ASC, apoptosis-associated speck-like protein containing a CARD; BTK, Bruton's tyrosine kinase; EP4, E-prostanoid 4; IKK, IκB kinase; JNK1, c-Jun ...： tw | tw。

Caspase-1/ASC Inflammasome-Mediated Activation of IL-1β–ROS ...。

2014年11月5日 · In this study, we have utilized wild-type (WT), ASC−/−, and NLRP3−/− macrophages and inhibition approaches to investigate the mechanisms ...。

Full article: Small molecule GL-V9 protects against colitis-associated ...。

GL-V9 treatment degraded NLRP3 inflammasome trigging autophagy. (A) Immunoblot analysis of ASC, processed caspase-1 and IL-1β in supernatants and lysates of ...